The paper identifies SBG1 as a regulator of suberin deposition in Arabidopsis roots through interaction with TOPPs, revealing a role in ABA signaling and stress resilience.

Nature Plants · May 4, 2026Peer-reviewedPlant Biology

Harnessing distinct tissue-resident immune niches via S100A9/TLR4 improves ketone, lipid, and glucose metabolism

Giulia Lucibello, Gloria Ursino, Pryscila D. S. Teixeira, Szabolcs Zahorán, Francesca Fanuele, Marinos Kallikourdis, Florian Visentin, Christelle Veyrat‐Durebex, Ariane Widmer, Yibo Wu, M. Cremonesi, Claes B. Wollheim, Perrine Castets, Giorgio Ramadori, Roberto Coppari

This study shows that S100A9-TLR4 signaling in immune cells improves metabolic disorders by modulating immune niches in the liver and skeletal muscle.

Endocrinology · Aug 24, 2025Peer-reviewedPhysiology

Strategic validation of variants of uncertain significance in ECHS1 genetic testing

Yoshihito Kishita, Ayumu Sugiura, Takanori Onuki, Tomohiro Ebihara, Tetsuro Matsuhashi, Masaru Shimura, Takuya Fushimi, Noriko Ichino, Yoshie Nagatakidani, Hitomi Nishihata, Kazuhiro R. Nitta, Yukiko Yatsuka, Atsuko Imai‐Okazaki, Yibo Wu, Hitoshi Osaka, , Yasushi Okazaki

This study validates variants of uncertain significance in ECHS1 using functional assays and multi-omics analysis, identifying new pathogenic variants and cases of mitochondrial disease.

Journal of Medical Genetics · Apr 13, 2023Peer-reviewedGenetic & Genomic Medicine

Genetic Loci and Metabolic States Associated With Murine Epigenetic Aging

Khyobeni Mozhui, Ake T. Lu, Caesar Z Li, Amin Haghani, Jose Vladimir Sandoval-Sierra, Yibo Wu, Robert W. Williams, Steve Horvath

This study identifies genetic loci and metabolic factors associated with epigenetic aging in mice, showing links between DNA methylation entropy, diet, and life expectancy.

eLife · Apr 7, 2022Peer-reviewedGenomics