Safety Signals Enable Single-Episode Active Avoidance paradigm and Expose Threat Generalization in Tuberous Sclerosis Complex
Andrew Vincent Gallagher, Amber Victoria Wilson, Saheed Adesile Lawal, Harshil Sanghvi, Javed Iqbal, Matthew Dickinson, Brandon Li, Daniel A. Llano, Prerana Shrestha
This study introduces a novel behavioral paradigm to assess threat discrimination and shows that oxytocin-modulated translational control stabilizes threat-safety discrimination, with disruptions leading to generalized avoidance in Tuberous Sclerosis Complex.
bioRxiv · Mar 3, 2026 · PreprintAnimal Behavior & Cognition