Marta Carroni

Lipid-facilitated opening of the ADAM10 sheddase revealed by enhanced sampling simulations

This study uses simulations to show that phosphatidylserine induces conformational changes in ADAM10, leading to its activation and reduced antibody binding.

Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes

This study develops DARPin T cell engagers that specifically target HLA/peptide complexes on tumor cells, showing high affinity and specificity through in vitro selection and structural analysis.

Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP

The paper presents the cryo-EM structure of the MecA/ClpC/ClpP complex from Staphylococcus aureus, revealing how MecA facilitates substrate transfer and how ClpC/ClpP interactions are regulated by ATPase activity.

Uromodulin velcro sheets and their interaction with uropathogenic E. coli

The paper shows Uromodulin forms salt-dependent velcro-like sheets that interact with UPEC pili, revealing structural mechanisms for UTI protection.

EMhub: a web platform for data management and on-the-fly processing in scientific facilities

EMhub is a web platform for managing scientific facility operations and data processing, with applications in CryoEM and other centers.

Unmasking AlphaFold: integration of experiments and predictions in multimeric complexes

This study introduces AF_unmasked, a method that integrates experimental data with AlphaFold predictions to improve the accuracy of large protein complex structures.

A simple pressure-assisted method for MicroED specimen preparation

This paper introduces a simple pressure-assisted method for preparing MicroED specimens, enabling control over ice thickness and handling diverse crystal samples.