Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identity
Rachel A Minerath, Rajesh K. Kasam, Casey O. Swoboda, Vikram Prasad, Kelly M. Grimes, N. Scott Blair, Hadi Khalil, Christina M. Alfieri, Logan Eads, Anthony J. Saviola, Mohamad Azhar, Lianjie Miao, Mingfu Wu, Michelle D. Tallquist, Kirk Charles Hansen, , Jeffery D. Molkentin
This study shows that TGFβ from cardiomyocytes programs fibroblast development and ECM environment to support cardiomyocyte maturation in the developing heart.
bioRxiv · Sep 22, 2025 · PreprintDevelopmental Biology