Preethi H. Gunaratne

Atlas-Guided Cell-Specific Transcriptomics Identifies Pathway-Level Remodeling of Human Hypothalamic CRH Neurons in Opioid Use Disorder

The paper identifies pathway-level remodeling in human hypothalamic CRH neurons in opioid use disorder using single-nucleus RNA sequencing and atlas-guided analysis.

Intra-Abdominal Bowel Dilation in Experimental Gastroschisis is Associated with a Modifiable Transcriptomic Program of Intestinal Dysfunction

The paper characterizes transcriptional changes in gastroschisis, showing that prenatal repair normalizes gene expression and bowel dilation.

Cell-type-specific architecture of the hypothalamus in a socially plastic vertebrate

The paper maps cell types in the hypothalamus of a social cichlid fish and identifies gene expression patterns linked to social status and behavior.

Autosomal dominant CDC45 deficiency with allelic expression bias causes a novel genetic disease of the immune system

The paper identifies a CDC45 variant causing immune disease with allelic bias, linking it to NK cell dysfunction and variable expressivity in a family.

CRISPR screening reveals genetic regulators associated with the evolution of eye degeneration

The paper identifies genetic regulators of eye degeneration in cavefish using CRISPR screening and functional assays.

Spatial Transcriptomics Reveals Inflammation and Trans-differentiation States of Acute Myeloid Leukemia in Extramedullary and Medullary Tissues

This study uses spatial transcriptomics to analyze AML in both medullary and extramedullary tissues, revealing inflammation and trans-differentiation states.

Single-nucleus transcriptomic analysis reveals the regulatory circuitry of myofiber XBP1 during regenerative myogenesis

This study shows that XBP1 in myofibers regulates muscle regeneration through cell-autonomous and non-autonomous mechanisms by affecting satellite cells and non-myogenic cells.

β1 integrins regulate cellular behaviors and cardiomyocyte organization during ventricular wall formation

This study investigates the role of β1 integrins in regulating cardiomyocyte behavior and organization during ventricular wall formation in mice, finding that their deletion disrupts tissue architecture and trabeculae formation.

MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: further evidence for opioid-induced neurovascular alterations

The paper analyzes miRNA-mRNA networks in postmortem brain and blood samples from opioid use disorder patients, identifying dysregulated pathways and potential therapeutic targets.