Tom H. Karlsen

This paper develops a humanized bile duct chip to model cholangiopathies and test treatments, showing drug effects and disease phenotypes.

This study conducts a GWAS on MRI-derived body composition measures, identifying genetic loci and genes associated with body composition and cardiometabolic diseases, with liver fat showing strong genetic associations.

This study examines how a major genetic risk factor for COVID-19 affects mortality and severity, finding stronger effects in younger adults.

This study performs a genome-wide association analysis of hemorrhoidal disease in 944,133 individuals, identifying 102 risk loci and linking them to vascular and tissue development pathways.

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.