Michele Migliore

The paper shows that different ion channel configurations and neuron shapes can produce similar electrophysiological behaviors in CA1 pyramidal neurons, demonstrating robust degeneracy.

The paper presents a full-scale in silico model of rat hippocampal CA1 integrating diverse experimental data and validates it through simulations of theta rhythm and other experiments.

This paper introduces a multiscale modelling framework for hippocampal CA1 that bridges micro and macro scales using a novel mean-field model, validated against spiking network models.

The paper introduces a method to generate heterogeneous copies of hippocampal CA1 neurons using A-GLIF models, ensuring firing dynamics fall within experimental ranges.

This study investigates the interaction between N-type Ca2+ channels and BK channels in mouse neocortical layer-5 pyramidal neurons, revealing their functional coupling and impact on AP shape and Ca2+ influx.

The paper compares neural activity patterns in the hippocampus after massed and distributed spatial training using c-Fos expression and machine learning.

The paper shows that T-type Ca2+ currents and persistent Na+ currents in ventral mEC stellate neurons increase excitability, distinguishing them from dorsal neurons.

The paper investigates how HCN and TASK-like channels affect dendritic impedance in layer 5 pyramidal neurons, finding that their combination best matches experimental impedance profiles.

This study investigates how cellular network connectivity influences the onset of epileptiform activity using computational models and suggests implications for experimental research.

This paper introduces a spiking neuronal network model inspired by hippocampal circuitry that can learn arbitrary sequences in a single trial, achieving higher efficiency and accuracy than abstract network models.

The paper shows circadian rhythms in hippocampal CA1 neurons and astrocytes affect synaptic plasticity through changes in NMDA receptor expression and astrocytic proximity to synapses, altering glutamate clearance and cognitive processing.

This paper integrates existing knowledge on rodent hippocampal CA1 synaptic anatomy and physiology into a coherent in silico resource.

The paper compares electrophysiological properties of pyramidal neurons in epileptic and non-epileptic human neocortex, finding reduced excitability in epileptic neurons due to increased K+ channel activity.