Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
Rachel M. Nakagawa, Andrew R. Beardsley, Sophia Durney, Mary-Kate Hayward, Vishvak Subramanyam, Nathaniel P. Meyer, Harrison Wismer, Hani Goodarzi, Valerie Marie Weaver, Daniel Van de Mark, Andrei Goga
This study shows that YAP activation in monolayer cultures causes resistance to EGFR/KRAS/BRAF pathway inhibitors, while spheroids are more sensitive, highlighting differences in culture systems for modeling cancer progression.
bioRxiv · Sep 26, 2024 · PreprintCancer Biology