Vishvak Subramanyam

State, a set-based transformer trained on over 100 million perturbed cells, predicts perturbation responses in new cellular contexts better than mean, linear and deep learning baselines.

This study shows APOE4 disrupts neuronal proteome dynamics by impairing proteostasis, leading to protein accumulation and cellular stress before Alzheimer's disease onset.

This study uses GENEVA to analyze drug response variations in cancer cells, revealing mitochondrial activation's role in KRAS inhibition and EMT as a resistance mechanism.

This study shows systemic hypoxia reduces solid tumor growth across multiple cancer types without resistance, through purine metabolism suppression and can be pharmacologically induced.

The paper identifies RBM42 as a key regulator of MYC translation in PDAC, showing its role in oncogenic transcript regulation and tumor growth.

This study shows that YAP activation in monolayer cultures causes resistance to EGFR/KRAS/BRAF pathway inhibitors, while spheroids are more sensitive, highlighting differences in culture systems for modeling cancer progression.

The paper systematically identifies post-transcriptional regulatory modules by integrating multimodal data on RBP interactions and functions.