Author

Jack D. Griffith

University of North Carolina at Chapel HillORCID 0000-0002-8357-8689Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Smaranda WillcoxiD· 2 shared Blossom DamaniaiD· 1 shared Cailyn MeyeriD· 1 shared Christine A. MillsiD· 1 shared Eva S. AntoniD· 1 shared Gerald S. ShadeliD· 1 shared Gregory D. BowmaniD· 1 shared Guannan Huang· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

Smaranda WillcoxORCID

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3 papers

Recent·Most cited

cGAS bends unpaired DNA to form an unconventional structure that hyperactivates the innate immune response

Shuangshuang Yang, Shuai Wu, Silian Chen, Xin Li, Iryna Chelepis, Smaranda Willcox, Katherine Camille Barnett, Xiaoqing Hu, Guannan Huang, W. June Brickey, Joseph A. Duncan, Wei-Chun Chou, Pengda Liu, William G. Fusco, Stephanie Torres, , Jenny P.‐Y. Ting

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

bioRxiv · May 25, 2026 · PreprintImmunology

The valine-arginine dipeptide repeat protein encoded by mammalian telomeric RNA appears highly expressed in mitosis and may repress global translation

Taghreed M. Al-Turki, Venkata Mantri, Smaranda Willcox, Christine A. Mills, Laura E. Herring, Su-Ji Cho, Hannah Lee, Cailyn Meyer, Eva S. Anton, Jack D. Griffith

bioRxiv · Jul 24, 2024 · PreprintMolecular Biology

Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein

Jayla C. Calhoun, Blossom Damania, Jack D. Griffith, Lindsey M. Costantini

The paper uses electron microscopy to map DNA-binding sites of KSHV RTA protein and identifies its oligomeric states when bound to viral DNA.

Journal of Virology · Sep 26, 2023Peer-reviewedMolecular Biology