Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6
Xiyun Ye, Peiyuan Zhang, Jason Tao, John C. K. Wang, Amirhossein Mafi, Nathalie M. Grob, Anthony J. Quartararo, Hannah T. Baddock, Leanne Jade G. Chan, Fiona Elizabeth McAllister, Ian T. Foe, Andrei Loas, Dan Eaton, Qi Hao, Aaron H. Nile, Bradley L. Pentelute
The paper designs a covalent peptide inhibitor, reactide, targeting the HPV16 E6-E6AP interaction to prevent p53 degradation.
Chemical Science · Jan 1, 2023Peer-reviewedMolecular Biology