Leanne Jade G. Chan

This study shows that inhibiting PTPN1/2 enhances alveolar macrophage anti-metastatic activity through IFN-gamma-STAT1 signaling, offering a therapeutic strategy for metastasis.

The paper compares pore structure and dynamics in bacterial microcompartment shell proteins under different geometries using molecular modeling and simulations.

The paper designs a covalent peptide inhibitor, reactide, targeting the HPV16 E6-E6AP interaction to prevent p53 degradation.

This study shows that programming mRNA decay with MazF can redirect cellular resources to synthetic circuits, enhancing target functions like fluorescent reporter expression and gluconate metabolism.