John C. K. Wang

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

The paper develops a stereopure PMO-gapmer ASO to target tau, showing improved safety and activity by controlling phosphorus stereochemistry.

This paper develops branched multimeric peptides that bind α-Klotho with high affinity and selectivity, enabling its detection and labeling in biological systems.

The paper designs a covalent peptide inhibitor, reactide, targeting the HPV16 E6-E6AP interaction to prevent p53 degradation.

The paper identifies and characterizes anti-TREM2 scFv antibodies that inhibit soluble TREM2 production.