Neuronal PARIS-STAT3 axis drives tau pathology and glial activation in Alzheimers disease
Ji-Yang Song, Fatih Akkentli, Heejin Jo, Jinhee Park, Shinwon Ha, Jos� Ochoa, Juan Carlos Troncoso, Sung-Ung Kang, Valina Lynn Dawson, Ted M. Dawson
This study shows that PARIS in neurons activates STAT3, leading to tau pathology and glial activation in Alzheimer's disease, and identifies the PARIS-STAT3 pathway as a therapeutic target.
bioRxiv · Dec 10, 2025 · PreprintNeuroscience