Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain
Sabine Lagger, John C. Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H. Ramsahoye, Miao Yu, Dina DeSousa, Christian Seiser, Chuan He, Guido Sanguinetti, Lawrence C. Sowers, Malcolm D. Walkinshaw, Adrian Peter Bird
The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.
PLoS Genetics · May 12, 2017Peer-reviewedMolecular Biology