Author

Pauline Larrous

Centre National de la Recherche ScientifiqueORCID 0000-0002-8410-0513Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Florence Margottin-GoguetiD· 2 shared Marina MoreliD· 2 shared Roy MatkoviciD· 2 shared Andrea CimarelliiD· 1 shared Axel CournaciD· 1 shared Benjamin MartiniD· 1 shared Cassandre GarnieriD· 1 shared Fabienne BejjaniiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Florence Margottin-GoguetORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintJun 20, 2025

Hicberg: Reconstruction of contact signals from repeated elements

Sébastien Gradit, Samuel Ortion, Pauline Larrous…·Axel Cournac

Hicberg reconstructs contact signals from repeated elements in genomes by statistically reassigning reads from Hi-C data, revealing new insights into their impact on chromosome architecture.

DOI 10.1101/2025.06.20.660295

Hi-Cstatistical model

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MicrobiologyJournal of VirologyPeer-reviewedApr 22, 2025

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

Pauline Larrous, Cassandre Garnier, Marina Morel…·Florence Margottin-Goguet

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

3 citations

humanmouse

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Molecular BiologyNature CommunicationsPeer-reviewedJan 10, 2022

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

Roy Matkovic, Marina Morel, Sophie Lanciano…·Florence Margottin-Goguet

The paper shows TASOR interacts with CNOT1 and other RNA degradation factors to repress HIV expression by promoting RNA degradation and H3K9me3 deposition.

54 citationstop 4%

humanDNA methylation

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