The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.

Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology

Comprehensive locus-specific L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites.

Sophie Lanciano, Claude Philippe, Arpita Sarkar, David Pratella, Cécilia Domrane, Aurélien J. Doucet, Dominic van Essen, Simona Saccani, Laure Ferry, Pierre‐Antoine Defossez, Gaël Cristofari

The paper profiles L1 DNA methylation at single-locus resolution across normal and cancer cells, revealing how methylation and transcription interact with L1 integration sites.

Cell Genomics · Feb 1, 2024Peer-reviewedGenomics

Targeted nanopore resequencing and methylation analysis of LINE-1 retrotransposons

Arpita Sarkar, Sophie Lanciano, Gaël Cristofari

The paper describes a targeted nanopore sequencing method to sequence and analyze DNA methylation of LINE-1 retrotransposons with high coverage and haplotype resolution.

Methods in molecular biology · Nov 30, 2022Peer-reviewedGenomics

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

Roy Matkovic, Marina Morel, Sophie Lanciano, Pauline Larrous, Benjamin Martin, Fabienne Bejjani, Virginie Vauthier, Maike M. K. Hansen, Stéphane Emiliani, Gaël Cristofari, Sarah Gallois‐Montbrun, Florence Margottin-Goguet

The paper shows TASOR interacts with CNOT1 and other RNA degradation factors to repress HIV expression by promoting RNA degradation and H3K9me3 deposition.

Nature Communications · Jan 10, 2022Peer-reviewedMolecular Biology