Author

Florence Margottin-Goguet

Centre National de la Recherche ScientifiqueORCID 0000-0002-3124-6690Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Marina MoreliD· 3 shared Pauline LarrousiD· 2 shared Roy MatkoviciD· 2 shared Andrea CimarelliiD· 1 shared Asier Sáez‐CirióniD· 1 shared Audrey DumasiD· 1 shared Benjamin MartiniD· 1 shared Cassandre Garnier· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Marina MorelORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The lysosomal glutamine transporter SLC38A7/SNAT7 modulates SAMHD1 antiviral activity and promotes HIV-1 production in human macrophages

Floriane Herit, Gabrielle Lê-Bury, Quentin Provôt, Deborah To-Puzenat, Julie Haagen, Matozo de Souza T, Audrey Dumas, Marina Morel, Florence Margottin-Goguet, Corinne Sagné, Asier Sáez‐Cirión, Florence Niedergang

bioRxiv · Mar 6, 2026 · PreprintMicrobiology

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

Pauline Larrous, Cassandre Garnier, Marina Morel, Michael M. Martin, Karima Zarrouk, Sarah Maesen, Roy Matkovic, Andrea Cimarelli, Lucie Etienne, Florence Margottin-Goguet

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

bioRxiv · Mar 7, 2024Microbiology

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

Roy Matkovic, Marina Morel, Sophie Lanciano, Pauline Larrous, Benjamin Martin, Fabienne Bejjani, Virginie Vauthier, Maike M. K. Hansen, Stéphane Emiliani, Gaël Cristofari, Sarah Gallois‐Montbrun, Florence Margottin-Goguet

The paper shows TASOR interacts with CNOT1 and other RNA degradation factors to repress HIV expression by promoting RNA degradation and H3K9me3 deposition.

Nature Communications · Jan 10, 2022Peer-reviewedMolecular Biology