Axel Cournac

The paper uses GPSeq to map the budding yeast genome's radial organization, revealing that centromeres and telomeres constrain chromatin positioning, and GC-content organizes chromatin in their absence.

Hicberg reconstructs contact signals from repeated elements in genomes by statistically reassigning reads from Hi-C data, revealing new insights into their impact on chromosome architecture.

The paper shows that sister chromatid cohesion inhibits cohesin-mediated DNA loop expansion during G2 phase.

The paper investigates how transcription and cohesin complexes influence genome organization in yeast, showing transcription induces DNA borders and loops independently of SMC complexes.

The paper identifies how the 2μ plasmid in yeast binds to inactive chromosomal regions through nucleosome signals and RNA Pol II depletion, revealing a stable and rapid tethering mechanism.

Chromosight detects patterns in Hi-C contact maps with greater sensitivity and speed than existing methods, applicable to various genomes.

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.

The paper identifies Eco1's role in negatively regulating cohesin translocase activity during yeast mitosis, affecting DNA loop extrusion and chromosome folding.

This study applies meta3C to analyze the genomic structure of the mouse gut microbiome, enabling de novo assembly of bacterial chromosomes in a complex ecosystem.