Geert Loo

Indigenous Yanomami gut microbiota protects against diet-induced metabolic dysfunction

This study transplants gut microbiota from Indigenous Yanomami and urban donors into mice to show Yanomami microbiota protects against diet-induced metabolic dysfunction.

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation

This study shows OTULIN prevents keratinocyte death and skin inflammation by promoting canonical Wnt signaling through regulation of β-catenin ubiquitination.

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress

This study shows LUBAC activates AMPK and OTULIN restricts it, affecting metabolic responses to energy stress in cells, mice, and flies.