Cancer BiologybioRxivPreprint
The non-kinase function of CDK6 is a key driver of acquired resistance to CDK4/6 inhibitors in Estrogen Receptor-positive breast cancer
S. M. Nashir Udden, Baishan Jiang, Kamal Pandey…·Prasanna G. Alluri
This study shows that CDK6's non-kinase function drives resistance to CDK4/6 inhibitors in ER+ breast cancer, challenging the assumption that kinase inhibition is the main therapeutic target.
DOI 10.1101/2025.11.11.687883