Noelle Sevilir Williams

This study shows that CDK6's non-kinase function drives resistance to CDK4/6 inhibitors in ER+ breast cancer, challenging the assumption that kinase inhibition is the main therapeutic target.

This study maps tryptophan metabolites across multiple tissues, sexes, and ages in mice, revealing significant variations in metabolism that could inform disease-targeted therapies.

The paper identifies NVL as a target for cancer therapy, showing that its inhibition by MM17 and MM927 suppresses tumor growth through ribosome biogenesis disruption.

The paper identifies TXNRD1 as a therapeutic target in KRAS-WT and KRASi-resistant lung cancers by showing TRXR1 inhibition induces ferroptosis through redox mechanisms.

This study creates inducible EWSR1-FLI1 degron alleles in tumor cell lines to control fusion oncoprotein expression, showing reversible cell cycle arrest and tumor growth suppression in xenografts.

The paper identifies mefloquine analogs with broad-spectrum antifungal activity, effective against Candida auris in vivo.

This study identifies Caveolin-1 as a context-dependent regulator of survival signaling in Ewing Sarcoma, revealing a reversible CD99High state with enhanced survival.

This study evaluates the efficacy of TAK-925 and ARN-776, HCRTR2 agonists, in reducing cataplexy and promoting wakefulness in narcoleptic mice.