Mohammad Athar

Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming

This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy

The paper develops a 3D lung tumor model to evaluate immunotherapy response and identifies biomarkers for predicting immune checkpoint inhibitor efficacy in NSCLC.

Integrative systems biology framework discovers common gene regulatory signatures in multiple mechanistically distinct inflammatory skin diseases

The paper identifies common gene regulatory signatures across multiple inflammatory skin diseases using an integrative systems biology framework and proposes potential drug targets.

Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells

The paper compares transcriptome data from SARS-CoV-2 and other respiratory virus infections in human lung epithelial cells to identify genes and pathways associated with SARS-CoV-2 infection.

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

The paper constructs a human-SARS-CoV-2 interactome using network biology and multiomics data to identify key targets and regulatory circuits involved in SARS-CoV-2 pathogenesis.