Xiao-Qing Dai

Cisplatin exposure dysregulates pancreatic islet function in male mice

This study shows cisplatin exposure impairs pancreatic islet function in male mice by disrupting insulin secretion and causing DNA damage in beta cells.

HumanIslets: An integrated platform for human islet data access and analysis

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

The paper integrates single-cell multiomic data with genetics to identify gene regulatory changes in beta cells associated with type 2 diabetes.

HNF1α transcriptional activation and repression maintain human islet α and β cell function

This study investigates how HNF1A regulates human islet cell function by combining genetic, transcriptomic, and functional assays, revealing its role in maintaining insulin and glucagon secretion.

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes

This study links transcriptomic heterogeneity in pancreatic islet cells to their physiological function using a combined electrophysiological and single-cell RNA sequencing approach, identifying genes and pathways associated with diabetes-related dysfunction.

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.