Karina F. Rodriguez

Intermittent exposure to high ambient heat during the second half of gestation in mice causes mild alterations of reproductive endpoints in male embryos

This study shows that intermittent heat exposure during mid-to-late gestation in mice leads to reduced anogenital distance and increased hypospadias in male embryos, without affecting gene expression in the fetal testis.

Single-nucleus multiomics of murine gonadal cells reveals transcriptional regulatory network underlying supporting lineage differentiation

The paper identifies a transcriptional regulatory network in murine gonadal supporting cells that underlies sex differentiation, revealing how chromatin changes and gene expression drive Sertoli and granulosa cell fates.

NR2F2 regulation of interstitial to fetal Leydig cell differentiation in the testis: insights into differences of sex development

The paper identifies Nr2f2 as a regulator of interstitial to fetal Leydig cell differentiation in mice, linking its dysfunction to disorders of sex development.

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

This study uses single-nucleus multiomics to uncover gene regulatory networks and chromatin dynamics in murine PGCs during sex determination.