Barbara Nicol

Intermittent exposure to high ambient heat during the second half of gestation in mice causes mild alterations of reproductive endpoints in male embryos

This study shows that intermittent heat exposure during mid-to-late gestation in mice leads to reduced anogenital distance and increased hypospadias in male embryos, without affecting gene expression in the fetal testis.

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

This study uses single-nucleus multiomics to uncover gene regulatory networks and chromatin dynamics in murine PGCs during sex determination.

Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation

The paper identifies a PGR-A isoform-RUNX interaction that drives chromatin remodelling at promoters during ovulation, revealing a mechanism for ovulation-specific gene regulation.

Increased FOXL2 Expression Alters Uterine Structures and Functions

This study shows that increased FOXL2 expression in the female reproductive tract causes uterine structural and functional abnormalities, contributing to infertility and endometriosis progression.

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

The paper identifies RUNX1 as a conserved regulator of fetal ovarian supporting cell identity, showing its interaction with FOXL2 in maintaining granulosa cell fate across species.