Humphrey Hung‐Chang Yao

This study shows that intermittent heat exposure during mid-to-late gestation in mice leads to reduced anogenital distance and increased hypospadias in male embryos, without affecting gene expression in the fetal testis.

The paper identifies a transcriptional regulatory network in murine gonadal supporting cells that underlies sex differentiation, revealing how chromatin changes and gene expression drive Sertoli and granulosa cell fates.

The paper identifies Nr2f2 as a regulator of interstitial to fetal Leydig cell differentiation in mice, linking its dysfunction to disorders of sex development.

This paper develops a tamoxifen-inducible Cre mouse model, Nr2f2-iCreERT2, to specifically target interstitial cells in the reproductive system across developmental stages.

This study uses single-nucleus multiomics to uncover gene regulatory networks and chromatin dynamics in murine PGCs during sex determination.

The paper identifies a population of extra-genital mesenchymal cells essential for urethra closure in mouse embryos and shows their interaction with peri-urethra cells through Neuregulin 1.

The paper shows that Wolffian duct mesenchyme persists in female embryos and contributes to female reproductive tract formation through unique transcriptomic and anatomical changes.

SALSA is a method that identifies transcriptional profiles from minimal scRNA-seq data, achieving reproducible results with reduced computational and experimental costs.

This study shows that increased FOXL2 expression in the female reproductive tract causes uterine structural and functional abnormalities, contributing to infertility and endometriosis progression.

The paper identifies RUNX1 as a conserved regulator of fetal ovarian supporting cell identity, showing its interaction with FOXL2 in maintaining granulosa cell fate across species.