Parisha P. Shah

This study shows that mechanical-nuclear signaling in alveolar fibroblasts influences lung regeneration by modulating transcriptional identity and epithelial repair after injury.

The paper identifies hnRNPK as a key regulator of LAD positioning and reveals two distinct LAD classes based on epigenetic marks.

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

This study identifies spurious intragenic transcription as a conserved hallmark of mammalian cellular senescence and tissue aging, impacting cellular health and transcriptional networks.

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.

The paper identifies transcription factors that maintain cell identity by analyzing their responsiveness to perturbations in human iPSC-derived cardiac myocytes and fibroblasts.

This study identifies a BRD4-GATA4 interaction that regulates mitochondrial homeostasis in adult cardiomyocytes by modulating gene expression related to energy production.

The paper shows that RecA's ATPase activity prevents toxic DNA-bound complexes formed by erroneous binding to undamaged dsDNA in E. coli.