Author

Polly A. Machin

Babraham InstituteORCID 0000-0002-8481-8488Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Adam T. McCormackiD· 1 shared Anna G. RobertsiD· 1 shared David A. BakeriD· 1 shared David C. HornigoldiD· 1 shared Elisa BenettiiD· 1 shared Elpida TsonouiD· 1 shared Gemma K. KinsellaiD· 1 shared Heidi C. E. WelchiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Adam T. McCormackORCID

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1 paper

Recent·Most cited

Prex1 controls glucose homeostasis by limiting glucose uptake and mitochondrial metabolism in liver through GEF-independent regulation of Gpr21

Julia Y. Chu, Elpida Tsonou, Polly A. Machin, Kirsty MacLellan‐Gibson, Anna G. Roberts, Stephen A. Chetwynd, Adam T. McCormack, John C. Stephens, Elisa Benetti, Gemma K. Kinsella, David A. Baker, David C. Hornigold, Heidi C. E. Welch

This study shows Prex1 regulates glucose homeostasis by reducing glucose uptake and mitochondrial metabolism in the liver, independent of its catalytic activity, through Gpr21 inhibition.

bioRxiv · Apr 14, 2025 · PreprintPhysiology