Derin B. Keskin

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

This study identifies a novel CD8+ TIL subset that uses lymphotoxin and IFN pathways to kill cancer cells, linking LTB expression to clinical response in melanoma.

This study developed a DNA origami-based cancer vaccine that co-delivers antigen and CpG immune adjuvant with an optimal nanospacing for Th1 immune polarization.

The paper uses gene expression, clustering, and ANN classification of single-cell transcriptomes to predict therapy outcomes in CLL patients.

This paper develops a supervised ANN model to classify PBMC subtypes across multiple studies, achieving 94% 5-class accuracy with high consistency across protocols.