Author

Olivia J. Young

Harvard UniversityORCID 0000-0002-2252-6623Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

William M. ShihiD· 3 shared Christopher M. WintersingeriD· 2 shared Giorgia IsinelliiD· 2 shared Ick Chan KwoniD· 2 shared Ju Hee RyuiD· 2 shared Yang C. ZengiD· 2 shared Amanda R. GravelineiD· 1 shared Andyna VernetiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSynthetic Biology

William M. ShihORCID

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3 papers

Recent·Most cited

Reusing excess staple oligonucleotides for economical production of DNA origami

Giorgia Isinelli, Christopher M. Wintersinger, Matthew Aquilina, Pascal Lill, Olivia J. Young, Jie Deng, William M. Shih, Yang C. Zeng

This paper demonstrates that reusing excess staple oligonucleotides with replenishment can reduce DNA origami production costs by up to 80%.

Nucleic Acids Research · Jun 6, 2025Peer-reviewedSynthetic Biology

Cargo quantification of functionalized DNA origami for therapeutic application

Olivia J. Young, Hawa Dembele, Anjali Rajwar, Ick Chan Kwon, Ju Hee Ryu, William M. Shih, Yang C. Zeng

The paper quantifies cargo on DNA origami nanoparticles using gel-based and fluorescence-based methods for therapeutic applications.

Small Methods · Dec 9, 2024Peer-reviewedSynthetic Biology

Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination

Yang C. Zeng, Olivia J. Young, Christopher M. Wintersinger, Frances M. Anastassacos, James I. MacDonald, Giorgia Isinelli, Maxence O. Dellacherie, Miguel C. Sobral, Haiqing Bai, Amanda R. Graveline, Andyna Vernet, Melinda Sanchez, Kathleen Mulligan, Young–Jin Choi, Thomas C. Ferrante, , William M. Shih

This study developed a DNA origami-based cancer vaccine that co-delivers antigen and CpG immune adjuvant with an optimal nanospacing for Th1 immune polarization.

bioRxiv · Jun 8, 2022 · PreprintSynthetic Biology