Radha Raghuraman

This study shows that AD pathology in the lateral entorhinal cortex (LEC) causes hyperactive neurons with poor firing fidelity and object coding defects, leading to LEC-specific memory impairments in a transgenic mouse model.

This paper introduces Earth Movers Distance (EMD) metrics to better characterize remapping in neurons encoding spatial memory, showing improved performance over Pearson correlation in capturing complex remapping events.