Gustavo A. Rodriguez

This study examines how advanced amyloid beta pathology in APP NL-G-F mice affects spatial coding and neuronal activity in the medial entorhinal cortex, revealing impaired spatial information processing and hyperactivity.

This paper introduces Earth Movers Distance (EMD) metrics to better characterize remapping in neurons encoding spatial memory, showing improved performance over Pearson correlation in capturing complex remapping events.

This study shows that reducing Aβ-induced hyperactivity in the entorhinal cortex decreases Aβ and tau pathology in a mouse model of Alzheimer's disease.