S. Abid Hussaini

This study examines how advanced amyloid beta pathology in APP NL-G-F mice affects spatial coding and neuronal activity in the medial entorhinal cortex, revealing impaired spatial information processing and hyperactivity.

This study shows that AD pathology in the lateral entorhinal cortex (LEC) causes hyperactive neurons with poor firing fidelity and object coding defects, leading to LEC-specific memory impairments in a transgenic mouse model.

The paper introduces two open-source tools for analyzing temporal and spatial properties of local field potentials (LFPs) to address gaps in existing tools.

This paper introduces Earth Movers Distance (EMD) metrics to better characterize remapping in neurons encoding spatial memory, showing improved performance over Pearson correlation in capturing complex remapping events.

This study shows that reducing Aβ-induced hyperactivity in the entorhinal cortex decreases Aβ and tau pathology in a mouse model of Alzheimer's disease.