Bjoern Schwer

HiFiRe3 improves rare structural variant detection by reducing artifacts through error suppression and correction strategies across long and short-read sequencing platforms.

This study shows that neuronal DNA double-strand breaks, even when accumulated due to loss of C-NHEJ, do not drive brain aging or neurodegeneration in mice.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

The paper maps R-loops in neural stem/progenitor cells and finds they are associated with early replicating, transcribed regions but not with recurrent DSB clusters in long genes.