David L. Deitcher

The paper investigates how s-LNv clock neurons regulate sleep through neuropeptide release and cytoneme-mediated communication with l-LNv neurons.

The paper shows that Drosophila clock neurons capture circulating neuropeptide vesicles in anticipation of release, independent of axonal expansion or calcium signaling.

The paper develops a machine learning pipeline to classify seizure stages in Drosophila mutants, revealing genotype-specific patterns in seizure behavior.

The paper identifies a protein complex containing Na+/K+ ATPase and Jus that prevents epileptogenesis in Drosophila by regulating neural activity.

The paper shows that cAMP signaling opens dilating synaptic fusion pores for releasing large proteins, while Ca2+ triggers narrower pores for smaller cargo.

The paper shows that Drosophila clock neurons release neuropeptides from different compartments at different times, with somatic release controlled by IP3 and terminal release by Ca2+.