Kyle Muir

Assembly and phospho-regulatory mechanisms of the budding yeast outer kinetochore KMN complex

This study uses cryo-EM to reveal structural mechanisms of KMN complex assembly and phospho-regulation in budding yeast kinetochores.

A bipartite mechanism for condensin II activation in mitosis

This study identifies a bipartite mechanism for condensin II activation in mitosis, showing how M18BP1 relieves autoinhibition and enables DNA loop formation.

Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays

The paper determines cryo-EM structures of the CCAN complex bound to different DNA sequences to understand its architecture on centromeric α-satellite CENP-A nucleosome arrays.

Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.

Structural basis for the inhibition of the SARS-CoV-2 RNA-dependent RNA polymerase by favipiravir-RTP

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.