Author

Long-Fei Wu

Howard Hughes Medical InstituteORCID 0000-0002-0635-1624Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

John D. SutherlandiD· 2 shared Christopher J. RussoiD· 1 shared Dari KimaniusiD· 1 shared David BarfordiD· 1 shared Francesca CosciaiD· 1 shared Jack W. SzostakiD· 1 shared Jan LöweiD· 1 shared Kasim SaderiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

John D. SutherlandORCID

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2 papers

Recent·Most cited

Nonenzymatic loop-closing ligation generates RNA hairpins and is a template-free way to assemble functional RNAs

Long-Fei Wu, Ziwei Liu, Samuel J. Roberts, Meng Su, Jack W. Szostak, John D. Sutherland

This study demonstrates nonenzymatic loop-closing ligation can assemble functional RNA hairpins without templates, enabling the formation of complex RNA structures.

bioRxiv · Nov 19, 2021 · PreprintSynthetic Biology

Structural basis for the inhibition of the SARS-CoV-2 RNA-dependent RNA polymerase by favipiravir-RTP

Katerina Naydenova, Kyle Muir, Long-Fei Wu, Ziguo Zhang, Francesca Coscia, Mathew James Peet, Pablo Castro‐Hartmann, Qian Pu, Kasim Sader, Kyle C. Dent, Dari Kimanius, John D. Sutherland, Jan Löwe, David Barford, Christopher J. Russo

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.

bioRxiv · Oct 21, 2020 · PreprintMolecular Biology