Jorge Lázaro

Systematic differences in protein stability underlie species-specific developmental tempo

The paper identifies slower protein degradation in human cells compared to mice, linking protein stability differences to interspecies variations in developmental tempo.

Metabolic activities are selective modulators for individual segmentation clock processes

This study investigates whether metabolic activities act as global modulators of the segmentation clock, finding they are selective modulators with varied effects on key processes.

A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals

The paper uses stem cell differentiation to study developmental tempo scaling across mammals and finds that segmentation clock periods correlate with phylogeny and biochemical kinetics of HES7, but not metabolic rates.

Temporal patterning of the central nervous system by a shared transcription factor code

The paper identifies a temporal patterning program in vertebrate neurons controlled by transcription factors and the TGFβ pathway, showing its role in generating neuronal diversity.

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

The paper investigates how the pioneer factor Zelda controls gene expression timing through transient chromatin interactions in Drosophila embryos.