Author

Alysa Kasen

Van Andel InstituteORCID 0000-0002-8535-016XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Michael X. HendersoniD· 2 shared An Phu Tran Nguyen· 1 shared Ariel LouwrieriD· 1 shared Colt D. CapaniD· 1 shared Darren J. MooreiD· 1 shared Dylan J. Dues· 1 shared Elizabeth BretoniD· 1 shared Erin T. WilliamsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Michael X. HendersonORCID

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2 papers

Recent·Most cited

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency

Alysa Kasen, Sofia Lövestam, Elizabeth Breton, Lindsay K. Meyerdirk, Jacob Alec McPhail, Kristin Piché, Ariel Louwrier, Colt D. Capan, Hyoungjoo Lee, Sjors H. W. Scheres, Michael X. Henderson

This study shows that tau filament seeding capacity depends on both core structure and phosphorylation in the fuzzy coat, with phospho-mimetic residues restoring activity in modified tau.

Nature Communications · Oct 17, 2025Peer-reviewedNeuroscience

Pathological α-synuclein elicits granulovacuolar degeneration independent of tau

Dylan J. Dues, Madalynn L. Erb, Alysa Kasen, Naman Vatsa, Erin T. Williams, An Phu Tran Nguyen, Michael X. Henderson, Darren J. Moore

This study shows that pathological α-synuclein can cause granulovacuolar degeneration independently of tau, using a mouse model of α-synucleinopathy.

Translational Neurodegeneration · Jun 19, 2025Peer-reviewedNeuroscience