Author

Valerie M. Irizarry-Negron

University of PennsylvaniaORCID 0000-0002-8542-726XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Amy C. GladsteiniD· 2 shared David M. FeldseriD· 2 shared Keren M. AdleriD· 2 shared Carson D. PoltorackiD· 1 shared Charles Solomon Akino MercyiD· 1 shared Dain A. RuiziD· 1 shared Dmitri A. PetroviD· 1 shared Haiqing XuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Amy C. GladsteinORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedJun 15, 2026

Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer

Keren M. Adler, Haiqing Xu, Amy C. Gladstein…·David M. Feldser

This study shows tumor suppressor genotype affects immune cell recruitment and tumor growth in KRAS-driven lung cancer with varying neoantigen expression.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 25, 2025

The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer

Amy C. Gladstein, Carson D. Poltorack, Charles Solomon Akino Mercy…·David M. Feldser

The paper shows that H3K36M oncohistone inhibits NSD2, leading to SETD2-dependent antiviral immune response and tumor clearance in KRAS-driven lung cancer.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky