Author

Keren M. Adler

University of PennsylvaniaORCID 0000-0002-5810-9602Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Amy C. GladsteiniD· 2 shared David M. FeldseriD· 2 shared Valerie M. Irizarry-NegroniD· 2 shared Carson D. PoltorackiD· 1 shared Charles Solomon Akino MercyiD· 1 shared Dain A. RuiziD· 1 shared Dmitri A. PetroviD· 1 shared Haiqing XuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Amy C. GladsteinORCID

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2 papers

Recent·Most cited

Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer

Keren M. Adler, Haiqing Xu, Amy C. Gladstein, Valerie M. Irizarry-Negron, Maggie R. Robertson, Katherine R. Doerig, Dmitri A. Petrov, Monte M. Winslow, David M. Feldser

This study shows tumor suppressor genotype affects immune cell recruitment and tumor growth in KRAS-driven lung cancer with varying neoantigen expression.

Nature Communications · Jun 15, 2026Peer-reviewedCancer Biology

The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer

Amy C. Gladstein, Carson D. Poltorack, Charles Solomon Akino Mercy, Sharan Venkatesh, Keren M. Adler, Maggie R. Robertson, Stephanie Stransky, Valerie M. Irizarry-Negron, Dain A. Ruiz, Nelson F. Freeburg, Simone Sidoli, Irfan Ahmed Asangani, Sydney M. Shaffer, David M. Feldser

The paper shows that H3K36M oncohistone inhibits NSD2, leading to SETD2-dependent antiviral immune response and tumor clearance in KRAS-driven lung cancer.

bioRxiv · May 25, 2025 · PreprintCancer Biology