Author

Dain A. Ruiz

University of PennsylvaniaORCID 0000-0001-6080-8288Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Amy C. GladsteiniD· 1 shared Carson D. PoltorackiD· 1 shared Charles Solomon Akino MercyiD· 1 shared David M. FeldseriD· 1 shared Irfan Ahmed AsanganiiD· 1 shared Keren M. AdleriD· 1 shared Maggie R. RobertsoniD· 1 shared Nelson F. FreeburgiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Amy C. GladsteinORCID

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1 paper

Recent·Most cited

The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer

Amy C. Gladstein, Carson D. Poltorack, Charles Solomon Akino Mercy, Sharan Venkatesh, Keren M. Adler, Maggie R. Robertson, Stephanie Stransky, Valerie M. Irizarry-Negron, Dain A. Ruiz, Nelson F. Freeburg, Simone Sidoli, Irfan Ahmed Asangani, Sydney M. Shaffer, David M. Feldser

The paper shows that H3K36M oncohistone inhibits NSD2, leading to SETD2-dependent antiviral immune response and tumor clearance in KRAS-driven lung cancer.

bioRxiv · May 25, 2025 · PreprintCancer Biology