Application of Large Language Models for Annotating Genes into Reactome Pathways
Guanming Wu, Lisa R. Matthews, Nathan Boyer, Marija Vuković Milačić, Deidre Beavers, Nancy T. Li, Bruce May, Karen Rothfels, Veronica Shamovsky, Ralf Stephan, Marc E. Gillespie, Henning Hermjakob, Peter D’Eustachio, Lincoln David Stein
This paper applies large language models to assist in gene annotation into Reactome pathways, showing promising results in supporting curation workflows.
bioRxiv · Dec 23, 2025 · PreprintBioinformatics