Hong Yue

This study shows that RGS6 inhibits platelet activation and arterial thrombosis by modulating P2Y12/Gi signaling in mice.

This study shows that SARS-CoV-2 Spike protein promotes lung tumorigenesis via TYMP-dependent mechanisms, increasing lung cancer risk in COVID-19 survivors, especially smokers.

This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.