Bing Chen

The paper investigates how antibody affinity maturation and light-chain pairing contribute to neutralizing evolved SARS-CoV-2 variants, identifying mechanisms that enable anticipatory immune breadth.

The paper reports a cryo-EM structure of the S2 fragment of SARS-CoV-2 after S2 cleavage, showing it represents a late fusion intermediate, and shows that S2 cleavage accelerates membrane fusion.