Effect of the S2' site cleavage on SARS-CoV-2 spike
Wei Kang Shi, G. M. Jonaid, Md. Golam Kibria, Jacob Allen, Hanqin Peng, Sophia Rits‐Volloch, Haisun Zhu, Shaowei Wang, Richard M. Walsh, Jianming Lu, Bing Chen
The paper reports a cryo-EM structure of the S2 fragment of SARS-CoV-2 after S2 cleavage, showing it represents a late fusion intermediate, and shows that S2 cleavage accelerates membrane fusion.
Nature Communications · Nov 27, 2025Peer-reviewedBiochemistry