Author

Qing Xiong

Wuhan UniversityORCID 0000-0002-8656-2041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Organism:multiple species· 1

Frequent Co-Authors

Chen LiuiD· 2 shared Chengbao Ma· 2 shared David VeesleriD· 2 shared Huan YaniD· 2 shared Risako GeniD· 2 shared Young‐Jun ParkiD· 2 shared Abeer N. AlshukairiiD· 1 shared Amin AddetiaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMicrobiology

Chen LiuORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ACE2 utilization of HKU25 clade MERS-related coronaviruses with broad geographic distribution

Chen Liu, Young‐Jun Park, Chengbao Ma, Cameron Stuart, Risako Gen, Yucheng Sun, Xiao Yi Yang, M C Lin, Qing Xiong, Jun-Yu Si, Peng Liu, David Veesler, Huan Yan

The paper shows that HKU25 clade MERS-related coronaviruses use ACE2 as a receptor, challenging prior beliefs that DPP4 was their main receptor.

bioRxiv · Feb 19, 2025 · PreprintMicrobiology

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

Young‐Jun Park, Chen Liu, Jimin Lee, Jack T Brown, Chengbao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K. Zepeda, Cameron Stewart, Amin Addetia, Caroline J. Craig, M. Alejandra Tortorici, Abeer N. Alshukairi, Tyler N. Starr, , David Veesler

HKU5 merbecoviruses use bat Pipistrellus abramus ACE2 and several artiodactyl ACE2s through a cryo-EM-defined binding mode distinct from other ACE2-using coronaviruses, showing independent evolution of ACE2 usage.

Cell · Feb 7, 2025Peer-reviewedBiochemistry✦ In-depth digest