Matthew J. Tyska

This study investigates EPS8's role in actin-based protrusions, finding it dampens growth and prolongs lifetime by acting as a leaky capper at filament barbed ends.

The paper shows IRTKS promotes Tir membrane insertion, which is essential for bacterial attachment and pedestal formation during EHEC infection.

This study identifies Spef1 as a microvillar component that regulates apical actomyosin contractility to maintain intestinal barrier function.

The paper shows that intermicrovillar adhesion complexes limit bacterial attachment to the small intestine brush border, with SFB remodeling actin to anchor to epithelial junctions.

This study identifies ACTN4 as a non-muscle α-actinin in cardiac sarcomeres, showing it regulates contractility, hypertrophy, and heart remodeling without disease hallmarks.

The paper shows that apical clathrin-coated pits regulate microvillar growth by controlling their location, timing, and size during epithelial differentiation.

The paper counts membrane-bound myosin motors in growing filopodia and finds their number is log-normally distributed, suggesting myosins contribute significant force comparable to actin polymerization.

This study uses advanced microscopy to reveal the ultrastructural organization of tuft cell cytoskeleton, showing co-aligned actin bundles and microtubules.

This study shows that loss of CDHR2 disrupts intermicrovillar adhesion complexes, leading to impaired junctional complexes and barrier function in transporting epithelia.

The paper identifies actin assembly and non-muscle myosin activity as drivers of dendrite retraction in a UNC-6/Netrin-dependent self-avoidance response in C. elegans.

The paper identifies muscle-specific stress fibers as essential sarcomere precursors and shows they form through distinct mechanisms compared to non-muscle stress fibers.