Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer's disease
Aderemi Caleb Aladeokin, Michael Jeltsch, Hayk Davtyan…·Jari Koıstınaho
The paper examines proteasome composition and activity in human iPSC-derived cortical neurons from early-stage sporadic Alzheimer's disease patients, finding increased 20S proteasome assemblies and proteolytic activity.